Hiv Replication


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Lentiviral Vector Systems for Gene Transfer by Gary L. Buchschacher,

Lentiviral Vector Systems for Gene Transfer by Gary L. Buchschacher,
The human immunodeficiency viruses (HIVs), in particular HIV-1, are the causative agent responsible for the current worldwide epidemic of acquired immunodeficiency syndrome (AIDS). A major effort has thus been underway over the past two decades to understand hiv replication and control this pathogen. During this time, an enormous knowledge base has accumulated regarding the role of viral factors in the HIV-1 life cycle, hiv replication and the interaction of HIV-1 with the host cell is becoming increasingly understood. Certain features of HIV, for example its ability to infect non-dividing cells, are being exploited in the development of novel gene therapy vehicles. This volume provides an overview of the current information regarding the HIV replication cycle hiv replication and will serve as an introduction to subsequent chapters that address specific aspects of lentiviral-based gene therapy.
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Mitochondrial DNA: Methods and Protocols by William C. Copeland,

Mitochondrial DNA: Methods and Protocols by William C. Copeland,
Mitochondria are semiautonomous organelles that contain their own DNA hiv replication and are responsible for the bulk of ATP synthesis in the eukaryotic cell. Their functions are linked to the aging process, apoptosis, sensitivities to anti-HIV drugs, hiv replication and possibly some cancers. This book provides research protocols that enable the analysis of mitochondrial DNA hiv replication and the proteins involved in its maintenance. The first section of the book provides protocols to analyze the DNA. The second section contains protocols to analyze the proteins hiv replication and enzymes that maintain mitochondrial DNA. These protocols will enable scientists to understand how mutations in the genes for mitochondrial DNA replication hiv replication and repair proteins contribute to disease, thus providing all researchers a starting point for investigating the cause of mitochondrial dysfunction hiv replication and disease.
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